Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice

Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice

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Abstract We investigated and compared the susceptibility of retinal blood flow regulation and neural function in mice developing type 2 diabetes.The longitudinal changes in retinal neuronal function and blood flow responses to a 10-min systemic BUTTER OIL hyperoxia and a 3-min flicker stimulation were evaluated every 2 weeks in diabetic db/db mice and nondiabetic controls (db/m) from age 8 to 20 weeks.The retinal blood flow and neural activity were assessed using laser speckle flowgraphy and electroretinography (ERG), respectively.The db/db mice had significantly higher blood glucose levels and body weight.

The resting retinal blood flow was steady and comparable between two groups throughout the study.Hyperoxia elicited a consistent TV Stand with Infrared Fireplace decrease, and flicker light an increase, in retinal blood flow in db/m mice independent of age.However, these flow responses were significantly diminished in db/db mice at 8 weeks old and then the mice became unresponsive to stimulations at 12 weeks.Subsequently, the ERG implicit time for oscillatory potential was significantly increased at 14 weeks of age while the a-wave and b-wave amplitudes and implicit times remained unchanged.

The deficiencies of flow regulation and neurovascular coupling in the retina appear to precede neural dysfunction in the mouse with type 2 diabetes.